Breast conserving surgery in combination with targeted intraoperative radiotherapy compared to mastectomy for in-breast-tumor-recurrence

Hans-Christian Kolberg , Helena Niesing , Jayant S Vaidya et al
Breast conserving surgery in combination with targeted intraoperative radiotherapy compared to mastectomy for in-breast-tumor-recurrence
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Background

Mastectomy is the standard treatment of in-breast-recurrence of breast cancer after breast conserving surgery (BCS) and external beam radiation therapy (EBRT). In selected cases, it is possible to preserve the breast if targeted intraoperative radiotherapy (TARGIT-IORT) can be given during the second lumpectomy. This is a comparative analysis of overall survival and quality of life (QoL).

Patients and methods: 

Patients in our database with in-breast-recurrence and either mastectomy or BCS and TARGIT-IORT were included. Identified patients were offered participation in a prospective QoL-analysis using the BREAST-Q questionnaire. The cohorts were compared for confounding parameters, overall survival, and QoL.

Conclusion:

Preserving the breast by use of TARGIT-IORT was safe with no re-recurrence and no detriment to overall survival in our analysis and led to a statistically significant improvement in physical wellbeing and incidence of lymphedema. These data should increase the confidence in offering breast preservation after in-breast-recurrence of breast cancer.

Read the full study here: https://pubmed.ncbi.nlm.nih.gov/36697057/

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