Longitudinal Prospective Evaluation of Quality of Life After Axillary Lymph Node Dissection

Jennifer Q Zhang, Giacomo Montagna, Varadan Sevilimedu, Kelly Abbate, Jillian Charyn, Babak Mehrara, Monica Morrow, Andrea V Barrio
Longitudinal Prospective Evaluation of Quality of Life After Axillary Lymph Node Dissection

Patients often fear axillary lymph node dissection (ALND) because of its associated complications; however, its effect on quality of life (QOL) is not well described. We aimed to evaluate the effect of ALND on QOL over time and to identify predictors of worse QOL.

Breast cancer patients undergoing ALND were enrolled in a prospective lymphedema screening study. Arm volumes were measured and QOL questionnaires completed at baseline, postoperatively, and at 6-month intervals. The upper limb lymphedema-27 questionnaire was used to assess the effect of upper extremity symptoms on QOL in three domains (physical, psychological, and social). Predictors of QOL were identified by univariate and multivariable regression analyses.

QOL scores initially decreased after ALND but improved by 6 months post-surgery. Decreases in QOL were independent of arm volume. Patients with worse QOL more often sought lymphedema therapy, although the effect of therapy on QOL remains unknown.

Read full article here: https://pubmed.ncbi.nlm.nih.gov/35364766/