Systematic Review: Oncological Safety of Reconstruction with Fat Grafting in Breast Cancer Outcomes

Pietro Gentile , Valerio Cervelli
Systematic Review: Oncological Safety of Reconstruction with Fat Grafting in Breast Cancer Outcomes
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Background: Autologous fat grafting (AFG) has become a commonly used procedure for breast reconstruction (BR) after cancer removal. Nevertheless, oncological considerations remain for AFG after breast cancer surgery.

Objectives: This article aims to evaluate the oncological safety of AFG in BR and its effect on disease-free survival (DFS) and local-regional recurrences (LRR).

Methods: A systematic review regarding the use of AFG in BR to identify a difference in incidence rates of LRR and DFS between patients who had AFG and controls was performed using PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus, and Cochrane databases. The protocol was developed following the Preferred Reporting for Items for Systematic Reviews-Protocols (PRISMA-P) guidelines. The included studies had to match predetermined criteria according to the PICOS approach.

Conclusions: AFG can, therefore, be performed safely in BR after breast cancer. Further, randomized controlled trials and related systematic reviews, as well as evidence-based medicine (EBM) studies of level 1, are required to consolidate the results of the studies identified in this systematic review.

Read the full article here: https://pubmed.ncbi.nlm.nih.gov/36180337/ 

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Go to the profile of Fereshteh Abbasvandi
over 1 year ago

Hello,thanks a lot for sharing,Is there any different between site of fat graft (intramuscular or submuscular or...)?