The patterns and spatial locations of local recurrence in breast cancer with implant-based reconstruction after mastectomy

Ji Hyeon Joo, Jung Dug Yang, Ho Yong Park, Jaehyeon Park, Zhen-Yu Wu, BeomSeok Ko, Park Jongmoo, Su Ssan Kim
The patterns and spatial locations of local recurrence in breast cancer with implant-based reconstruction after mastectomy

The European Society for Radiotherapy and Oncology (ESTRO) recently defined delineation guidelines for the clinical target volume for postmastectomy radiation therapy (PMRT) after immediate implant-based reconstruction for early-stage breast cancer. We analyzed the three-dimensional location and pattern of local recurrence in accordance with the reconstruction type and ESTRO-target volume.

This retrospective study involved patients who had undergone mastectomy with implant reconstruction between 2010 and 2019 and who had local recurrence as the first event. For mapping analysis, one subpectoral and one prepectoral implant patient were selected. All recurrence lesions were contoured and mapped in a representative case.

The ESTRO-target volume in PMRT after reconstruction encompassed most local recurrences in patients who underwent mastectomy with immediate implant reconstruction. Our results support the application of the ESTRO Advisory Committee for Radiation Oncology Practice consensus guideline for target volume of PMRT after immediate implant-based reconstruction for early-stage breast cancer.

Read full article here: https://pubmed.ncbi.nlm.nih.gov/35245569/